Revisiting ring-degenerate rearrangements of 1-substituted-4-imino-1,2,3-triazoles

• James T. Fletcher,
• Matthew D. Hanson,
• Joseph A. Christensen and
• Eric M. Villa

Beilstein J. Org. Chem. 2018, 14, 2098–2105, doi:10.3762/bjoc.14.184

• facilitated by a high throughput colorimetric assay to directly monitor the generation of a 4-nitroaniline byproduct. Keywords: colorimetric assay; condensation; imine exchange; rearrangement; 1,2,3-triazole; Introduction Examples of multidentate chelators comprised of 1,2,3-triazole units have surged in

DNA functionalization by dynamic chemistry

• Zeynep Kanlidere,
• Oleg Jochim,
• Marta Cal and
• Ulf Diederichsen

Beilstein J. Org. Chem. 2016, 12, 2136–2144, doi:10.3762/bjoc.12.203

• of nucleobase monomers. In case of an amine group on the backbone, a reversible imine exchange reaction with aldehyde modified nucleobases was performed (Figure 1a). In the presence of a thiol group on the backbone, a thioester exchange reaction with thioester modified nucleobases was expected

• well as the simultaneous functionalization of DNA oligonucleotides at various positions with different kind of functional units. Template-directed dynamic chemistry assay for the attachment of modified nucleobase monomers to an abasic backbone. a) Reversible imine exchange reaction. b) Reversible